Validation of treatment decision algorithms for paediatric tuberculosis in first-level care facilities in high-prevalence countries
Membres de l’équipe impliqués :
Marcy Olivier – Consortium lead,
Orne-Gliemann Joanna – Implementation researcher,
d’Elbée Marc – Health economics researcher
Roucher Clémentine – Project manager, Trial manager (effectiveness)
Etoa Cleia – Information system coordinator
Huyen Ton Nu Nguyet Minh – Statistician
Koskas Nicolas – Communication officer
Lebrun Natacha – Implementation project officer
Marques Priscilia – Administrative and financial officer
Ouédraogo Ismaila – eHealth4CHildTB Project manager
The aim of the Decide-TB project is to generate evidence for the implementation of a global approach based on the use of therapeutic decision algorithms (TDAs) for the screening, diagnosis and therapeutic decision-making of tuberculosis in children living in countries with a high burden of tuberculosis and low levels of health. This approach includes the use of a shorter treatment course for non-severe tuberculosis. The ADTs to be validated are those suggested by the WHO and two specific ADTs for two vulnerable groups: children living with HIV and children suffering from severe acute malnutrition. The project aims to facilitate the integration of this evidence into policy and practice.
The National Tuberculosis Programmes (NTP) of Zambia and Mozambique will implement this approach in district hospitals and primary health centres in 5 districts over a period of 2 years in the context of a programmatic pilot study. The approach will be evaluated in a hybrid study combining implementation and effectiveness, using a phased cluster randomised controlled trial. The project will develop digital tools to support monitoring and evaluation, clinical mentoring and supervision by NTPs. The project also includes a meta-analysis of individual patient data (IPD), using data from previously conducted paediatric TB diagnostic studies (TB-Speed, UMOYA, Rapaed).
Clémentine Roucher
clementine.roucher@u-bordeaux.fr
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