Project MUSICC

Australia Belgium France Netherlands Singapore United Kingdom United States

Project ongoing

www.musicc.org

Short description

Studies on controlled human infection (CHI) by SARS-CoV-2 and seasonal CoV OC43

Domains

  • Research

Themes

  • Communicable diseases
  • Health crises

Sub-themes

  • Vaccine research aimed at establishing the best correlates of protection and models of immune response in humans by carrying out a clinical trial of controlled inoculation of SARS-CoV2 into healthy volunteers (CHIM: controlled human infection models).
  • SISTM is involved in modelling the immune response

Countries

  • Australia
  • Belgium
  • France
  • Netherlands
  • Singapore
  • United Kingdom
  • United States

Participating teams in Bordeaux

SISTM

Partner institutions in France

UB International Alliance for Biological Standardization

International partner institutions

Imperial College London of Science Technology and Medicine (ICL), United Kingdom Washington University in St Louis
National Centre for Infectious Diseases
UCL Fred Hutchinson Cancer Center Leicester University Darthmouth College University of Cambridge Centre for Human Drug Research Liverpool School of Tropical Medicine Université Libre de Bruxelles University of New South Wales Yale University University of Oxford University of Maryland Baltimore University of Antwerp – Vaccinopolis Leids Universitair Medisch Centrum (LUMC) Erasmus MC

Activity summary

To address the limitations of existing intramuscular vaccines in reducing transmission and providing protection between different viral strains, the MUSICC (Mucosal Immunity in human Coronavirus Challenge) consortium will establish a comprehensive capability for the development and conduct of controlled human infection (CHI) studies with SARS-CoV-2 and seasonal CoV OC43, to establish correlates of transmission reduction, identify mechanisms of cross-protection and test the efficacy of new generation vaccines in protecting against infection and reducing/blocking transmission.

 

Project contacts

Rodolphe Thiebaut
Rodolphe.thiebaut@u-bordeaux.fr

Boris Hejblum
Boris.hejblum@u-bordeaux.fr

Melanie Prague
Melanie.prague@u-bordeaux.fr

Anton Ottavi
anton.ottavi@u-bordeaux.fr

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