Project SOLVE

Belgium Finland Italy Spain Switzerland

Project ongoing

Short description

Analysis of the shortcomings and difficulties of currently authorised SARS-CoV-2 vaccines

Domains

  • Research

Themes

  • Communicable diseases
  • Health crises
  • Health systems, governance and financing

Sub-themes

  • Vaccine research aimed at scientifically clarifying the mechanisms of action of different types of vaccine in order to provide public authorities with recommendations on the choice of vaccine types and vaccination strategies for a future pandemic.
  • SISTM is involved in modelling the immune response to different vaccines and comparing vaccine strategies. MART/EUCLID is involved in the drafting/regulatory submission of the planned vaccine trials.

Countries

  • Belgium
  • Finland
  • Italy
  • Spain
  • Switzerland

Participating teams in Bordeaux

MART/EUCLID SISTM

Partner institutions in France

Activity summary

The main aim of the SOLVE project is to decipher the mechanisms involved in inducing long-term immunity by directly comparing vaccine platforms, and to develop new vaccine concepts. The ultimate aim is to overcome the shortcomings and difficulties of the currently licensed SARS-CoV-2 vaccines.

In addition, the project will address crucial social issues relating to the acceptability of major vaccination campaigns and approaches to improving the implementation of the next generation of vaccines as part of a preparedness plan.
The implementation of second-generation vaccines, whose durability and safety have been demonstrated, must not be compromised by reluctance to use vaccines.

This pillar will focus on :
i) stakeholder involvement and empowerment, including the acceptability of vaccines and their characteristics ;
ii) regulatory integration of the preparation concept.

This last objective will be the focus of considerable effort and resources on the part of the consortium. One of the expected outcomes will be the definition of targeted vaccine education and regulatory strategies to accelerate the introduction of new vaccines to improve pandemic preparedness.

Project contacts

Melanie Prague
Melanie.prague@u-bordeaux.fr

Linda Wittkop
Linda.wittkop@u-bordeaux.fr

Anton Ottavi
anton.ottavi@u-bordeaux.fr

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